GETTING MY PKRRATING TO WORK

The activated enzyme then here phosphorylates its major substrate, the translational initiation component eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the integrate